We live in an age of “high tech” medicine which affects both health care recipients and physicians who are taught its many wonders and uses. It is easy in this atmosphere of specialization for clinicians, professors and medical students to become isolated and to ignore social issues which affect health care in its broadest sense.Individuals who are committed to the “common good” are the ones historically who have been effective change agents. It would be tragic simply to stand back and (...) allow the cynical and greedy to dominate any profession which deals with the poor, the uninsured and the homeless.It is imperative for physicians to take a broad view of today's problems in health care delivery systems, for they can have an enormous impact on the kind of world our children will inherit. It is essential for physicians to become involved in social concerns, and in improving health care delivery, at all levels in their practice.Given their power and prestige, it is crucial for physicians and aspiring physicians to have positive role models. Dr. Julius B. Richmond provides an admirable example of a physician who cares about his profession, his patients and his nation. Through his research, his public service and his teaching, Dr. Richmond has demonstrated the difference a single individual can make in improving the quality of life for all Americans. (shrink)

It has long been recognized that cancer onset and progression represent a type of reversion to an ancestral quasi‐unicellular phenotype. This general concept has been refined into the atavistic model of cancer that attempts to provide a quantitative analysis and testable predictions based on genomic data. Over the past decade, support for the multicellular‐to‐unicellular reversion predicted by the atavism model has come from phylostratigraphy. Here, we propose that cancer onset and progression involve more than a one‐off multicellular‐to‐unicellular reversion, and are (...) better described as a series of reversionary transitions. We make new predictions based on the chronology of the unicellular‐eukaryote‐to‐multicellular‐eukaryote transition. We also make new predictions based on three other evolutionary transitions that occurred in our lineage: eukaryogenesis, oxidative phosphorylation and the transition to adaptive immunity. We propose several modifications to current phylostratigraphy to improve age resolution to test these predictions. Also see the video abstract here: https://youtu.be/3unEu5JYJrQ. (shrink)

Man has the urge to thrust against the limits of language. Think for instance about one's astonishment that anything exists. This astonishment cannot be expressed in the form of a question and there is no answer to it. Anything we can say must, a priori, be nonsense.

I argue that sport hunting is a right thing according to Leopold’s land ethic. First, I argue that what Leopold means by a “thing” (“A thing is right...”) is not a human action, as is generally assumed, but rather a practice of conservation that is an activity connecting humans to the land. Such an “outdoor” activity emphasizes internal rewards and the achievement of excellence according to standards which at least partially define the activity. To say that hunting is a right (...) thing is to say that the practice of sport hunting tends in the direction of the land ethic. The actions of individual hunters are judged to be ethical or not by the standards of the practice; these standards are in turn evaluated by the precepts of the land ethic. Second, I discuss how the practical standards are evaluated. I argue that the concepts of integrity, stability, and beauty, contrary to some interpretations, are not inherent values of the biotic community, but rather labels carefully chosen by Leopold as three conduits for the ecological conscience necessary for the land ethic: the ethical, the ecological, and the aesthetic. I show that Leopold uses this model for his own evaluation of the practice of hunting as well as his evaluation of other practices of conservation. Thus, to ask about whether sport hunting is a right thing is to ask about the historical evolution of the standards of this practice and, of equal importance, about the future direction of these standards with regard to the land ethic. (shrink)

Although controversy concerning the morality of hunting is generally focused on sport hunting, sport hunting itself is not a morally distinctive kind of hunting. The understanding of hunting in general needs to be supplemented with reference to the goods which hunting seeks. Attempts to draw a moral distinction between sport and subsistence hunting are inadequate and historically suspect. Likewise, trying to establish sport hunting as morally distinctive by emphasizing its similarities to other sports also fails. Nevertheless, there are standards accepted (...) by hunters that support ethical judgments about hunting. Ethical hunting requires reentry into a community of nonhuman beings governed by ecology and evolution, not human constructs, the development of virtues such as tenacity, courage, moderation, and discipline, and the achievement of a heightened respect for the biotic community in which the hunt takes place. By means of such standards, we may yet be able to determine what good hunting is even though we are unable to determine whether sport hunting is good. (shrink)

It is well known that Augustine, Boethius, Anselm and Aquinas participated in a tradition of philosophical theology which determined God to be simple, perfect, immutable and timelessly eternal. Within the parameters of such an Hellenic understanding of the divine nature, they sought a clarification of one of the fundamental teachings of their Christian faith, the doctrine of the Trinity. These classical theists were not dogmatists, naively unreflective about the very possibility of their project. Aquinas, for instance, explicitly worried about and (...) fought to dispel the seeming contradiction between the philosophical requirement of divine simplicity and the creedal insistence on a threefold personhood in God. 1 Nevertheless, doubts abound. Philosophers otherwise friendly to Classical Theism still remain unsure about the coherence of affirming a God that is at once absolutely simple and triune. 2 A less friendly critic has even suggested that the theory of divine simplicity pressured Augustine and his medieval followers away from recognizing that real complexity within the life of God which Trinitarianism expresses. 3. (shrink)

Despite its importance, the linkage between genetic and cultural evolution has until now been little explored. An understanding of this linkage is needed to extend evolutionary theory so that it can deal for the first time with the phenomena of mind and human social history. We characterize the process of gene-culture coevolution, in which culture is shaped by biological imperatives while biological traits are simultaneously altered by genetic evolution in response to cultural history. A case is made from both theory (...) and evidence that genetic and cultural evolution are inseverable, and that the human mind has tended to evolve so as to bias individuals toward certain patterns of cognition and choice rather than others. With the aid of mathematical models we trace the coevolutionary circuit: The genes prescribe structure in developmental pathways that lay down endocrine and neural systems, imposing regularities in the development of cognition and behavior; these regularities translate upward into holistic patterns of culture, which can be predicted in the form of probability density distributions ; natural selection acts within human history to favor certain epigenetic rules over others; and the selection alters the frequencies of the underlying genes. The effects of genetic and cultural changes reverberate throughout the circuit and are consequently tested with the passage of each life cycle. In addition to modeling gene-culture coevolution, we apply methods from island biogeography and information theory to examine the cultural capacity of the genes, the factors determining the magnitude of cultural diversity, and the possible reasons for the uniqueness of the human achievement. (shrink)

The Standards of Ethical Conduct for Management Accountants (Statement 1C) promulgated by the National Association of Accountants on June 1, 1983, are described and critiqued in this article. Four major issues related to the issuance of the standards are discussed: (1) What are the basic requirements of any ethical system? Does Statement IC meet these requirements? (2) Should a professional be ethical? (3) If ethical behavior is desirable for management accountants, should such standards be formally expressed in writing? (4) If (...) the standards are expressed in writing, what format should be adopted for the content and how should the standards be expressed? (shrink)

Despite its importance, the linkage between genetic and cultural evolution has until now been little explored. An understanding of this linkage is needed to extend evolutionary theory so that it can deal for the first time with the phenomena of mind and human social history. We characterize the process of gene-culture coevolution, in which culture is shaped by biological imperatives while biological traits are simultaneously altered by genetic evolution in response to cultural history. A case is made from both theory (...) and evidence that genetic and cultural evolution are inseverable, and that the human mind has tended to evolve so as to bias individuals toward certain patterns of cognition and choice rather than others. With the aid of mathematical models we trace the coevolutionary circuit: The genes prescribe structure in developmental pathways that lay down endocrine and neural systems, imposing regularities in the development of cognition and behavior; these regularities translate upward into holistic patterns of culture, which can be predicted in the form of probability density distributions ; natural selection acts within human history to favor certain epigenetic rules over others; and the selection alters the frequencies of the underlying genes. The effects of genetic and cultural changes reverberate throughout the circuit and are consequently tested with the passage of each life cycle. In addition to modeling gene-culture coevolution, we apply methods from island biogeography and information theory to examine the cultural capacity of the genes, the factors determining the magnitude of cultural diversity, and the possible reasons for the uniqueness of the human achievement. (shrink)

Friendship, in its nature, purpose, and effects, has been an important concern of philosophy since antiquity. It was of particular significance in the life of Gilles Deleuze, one of the most original and influential philosophers of the late twentieth century. Taking L'Abécédaire de Gilles Deleuze -- an eight-hour video interview that was intended to be aired only after Deleuze's death -- as a key source, Charles J. Stivale examines the role of friendship as it appears in Deleuze's work and (...) life. Stivale develops a zigzag methodology practiced by Deleuze himself to explore several concepts as they relate to friendship and to discern how friendship shifts, slips, and creates movement between Deleuze and specific friends. The first section of this study discusses the elements of creativity, pedagogy, and literature that appear implicitly and explicitly in his work. The second section focuses on Deleuze's friendships with Foucault, Derrida, Claire Parnet, and Félix Guattari and reveals his conception of friendship as an ultimately impersonal form of intensity that goes beyond personal relationships. Stivale's analysis offers an intimate view into the thought of one of the greatest thinkers of our time. (shrink)

In this essay, we defend the design of the Salk polio vaccine trial and try to put some limits on the role schemata should play in designing clinical research studies. Our presentation is structured as a response to de Freitas and Pietrobon who identified the CONSORT statement as a schema that would have, had it existed at the time, ruled out the design of the Salk polio vaccine trial of 1954 in favor of a completely randomized controlled clinical trial. We (...) argue that large-scale public health interventions often require evidence beyond simple efficacy, the limit of what an RCT can provide, and that the design actually adopted for the Salk trial represented a reasonable—albeit imperfect—compromise. This is of more than historical interest in that many contemporary studies are of the scale and scope to require a more pragmatic, rather than explanatory, approach to study design. (shrink)

Should engineering ethics be taught? Despite the obvious truism that we all want our students to be moral engineers who practice virtuous professional behavior, I argue, in this article that the question itself obscures several ambiguities that prompt preliminary resolution. Upon clarification of these ambiguities, and an attempt to delineate key issues that make the question a philosophically interesting one, I conclude that engineering ethics not only should not, but cannot, be taught if we understand “teaching engineering ethics” to mean (...) training engineers to be moral individuals (as some advocates seem to have proposed). However, I also conclude that there is a justification to teaching engineering ethics, insofar as we are able to clearly identify the most desirable and efficacious pedagogical approach to the subject area, which I propose to be a case study-based format that utilizes the principle of human cognitive pattern recognition. (shrink)

The purpose of this paper is to review the rising influence of commercialism in American medicine and to examine some of the consequences of this trend. Increased competition subverts physician collegiality, draws hospitals into for-profit ownership and behavior, and leads clinical investigators into secrecy and possibly into bias and abuse. Medicine faces a deprofessionalization evidenced in loss of control over the clinical setting and over self-regulation. Health care becomes a commodity relying on cultivation of desires instead of satisfaction of needs, (...) even as many basic needs go unmet. Patients become consumers empowered with lawsuits and the connection of medicine to the relief of suffering is attenuated. Medical encounters are increasingly impersonal, dominated by specialization, technology, and bureaucracy. Patients are losing their physician-advocates to new conflicts of interests, physicians are losing their impulse to charity, and trust in the doctor-patient relationship and in medicine generally is eroding. (shrink)

Heidegger understands technology as an act of revealing rather than merely a human achievement. Within the modern era, technology represents the manner in which humans stand within and make manifest the open interplay and inter-relatedness that is world. The danger of this era is the extent to which everything has become available, accessible, and disposable to human manipulation, practically without limit. However, the very totalizing extent to which this is happening, and the forgetfullness that takes it all for granted, can (...) also make us suddenly aware that everything, including world itself, is at risk; that we ourselves are at risk; that we are the danger. He calls for an attitude of releasement that handles world with a sense of receiving, and not just taking, a sense of thankfulness. Such a change could directly impact how we see ourselves and our responsibilities as we go about developing and using technologies. (shrink)

That dichotomization is, at least under certain circumstances, a bad idea is not news. A well-known, early example is the biblical story of King Solomon, who used the absurdity of the procedure to help adjudicate a dispute between two women who each claimed to be the mother of a contested child. Solomon reasoned that his proposal to split the child into two, giving half to each woman, would be abhorrent to the real mother, and when one of the women objected (...) while the other thought the proposal was "only fair," the choice between the women was made obvious.Things, however, are not always so clear-cut, and it is not difficult to find arguments that point to the advantages that accrue to those that simplify matters.... (shrink)

This volume sets Berkeley's philosophy in its historical context by providing selections from: firstly, works that deeply influenced Berkeley as he formed his main doctrines; secondly, works that illuminate the philosophical climate in which those doctrines were formed; and thirdly, works that display Berkeley's subsequent philosophical influence. The first category is represented by selections from Descartes, Malebranche, Bayle, and Locke; the second category includes extracts from such thinkers as Regius, Lanion, Arnauld, Lee, and Norris; while reactions to Berkeley, both positive (...) and negative, are drawn from a wide range of thinkers - Leibniz, Baxter, Hume, Diderot, Voltaire, Reid, Kant, Herder, and Mill. (shrink)

It is perhaps most useful to approach the Doctor-Patient relationship (DPR) by admitting that it’s complicated. We review some of the strategies that have been employed to mitigate this complexity, zeroing in on one that promises to capture the main features of the DPR without eliminating some of its more important, existential components; pieces of the puzzle that must be retained if we are to avoid oversimplification and the errors that can arise by ignoring important foundational properties. We believe that (...) a useful way to look at the DPR and to capture essential features that must be balanced in the process is provided by Partnership Theory and its definition in terms of the so-called domination and partnership systems. We apply this theory to the DPR and investigate the implications of this application to health care. We see that in the absence of mitigating circumstances, adoption of the patient-as-partner model serves healthcare well and is flexible enough to accommodate circumstances that dictate modifications. (shrink)

The land ethic of Aldo Leopold has increasingly received attention as an example of an environmental virtue ethic. However, an important remaining question is how to cultivate and transmit environmental virtues. The answer to this question can be found in the pursuit of wild leisure. The classical view of leisure primarily as articulated in Aristotle’s Politics provides a good starting point for an examination of wild leisure. Leopold thought wild leisure was important and associated it with his land ethic. Leopold’s (...) view of wild leisure focused on the role of perception in ecological education and the habituation of virtue. The classical virtue of moderation when habituated by wild leisure becomes the central virtue required by an ecological conscience. Wild leisure educates just those intellectual and scientific virtues necessary for refined perception and prudence. These virtues provide connections between good citizenship and land citizenship. (shrink)

The Belmont Report’s distinction between research and the practice of accepted therapy has led various authors to suggest that these purportedly distinct activities should be governed by different ethical principles. We consider some of the ethical consequences of attempts to separate the two and conclude that separation fails along ontological, ethical, and epistemological dimensions. Clinical practice and clinical research, as with yin and yang, can be thought of as complementary forces interacting to form a dynamic system in which the whole (...) exceeds the sum of its parts. Just as effective clinical practice cannot exist without clinical research, meaningful clinical research requires the context of clinical practice. We defend this thesis by triangulation, that is, by outlining how multiple investigators have reached this conclusion on the basis of varied theoretical and applied approaches. More confidence can be placed in a result if different methods/viewpoints have led to that result. (shrink)

This article presents the rationale of a new approach to the debate between sociobiology and religion. In it, I outline a sociobiology that may generate alternative and competing hypotheses about the existence of gods as beings (theisms) and the nature of their participation in the universe. I examine the central theoretical issues of this sociobiology and discuss the strengths and weaknesses of a sociobiological approach to theological issues, including problems pertinent to nontheistic theologies. A concluding case is made for an (...) enriched and revitalized agenda in the dialogue between sociobiology and religion. While consistent with current research on gene‐culture coevolution, the article's treatment expands on earlier work to begin incorporating theoretical terms that carry a more direct theological impact. (shrink)

Memory exhibits episodic superposition, an analog of the quantum superposition of physical states: Before a cue for a presented or unpresented item is administered on a memory test, the item has the simultaneous potential to occupy all members of a mutually exclusive set of episodic states, though it occupies only one of those states after the cue is administered. This phenomenon can be modeled with a nonadditive probability model called overdistribution (OD), which implements fuzzy-trace theory's distinction between verbatim and gist (...) representations. We show that it can also be modeled based on quantum probability theory. A quantum episodic memory (QEM) model is developed, which is derived from quantum probability theory but also implements the process conceptions of global matching memory models. OD and QEM have different strengths, and the current challenge is to identify contrasting empirical predictions that can be used to pit them against each other. (shrink)

Gilles Deleuze is now regarded as one of the most radical philosophers of the twentieth century. His work has become hugely influential across a range of subjects, from philosophy and literature to art, architecture and cultural studies. Gilles Deleuze: Key Concepts brings together leading specialists from a variety of disciplines to introduce the central concepts in the work of Deleuze. The short and accessible chapters in this book each focus on a single concept and show not only what the concept (...) is but what it does. The contributors consider how the concepts are engaged, intersect, link and how they may deviate from other areas of postmodern thought. The concepts Deleuze employs in his writings are key to understanding his philosophical approach: they work to unsettle particular bodies of knowledge, to open them up and to link them to other concepts within and outside that body of knowledge. Aimed at a readership new to Deleuze and from disciplines outside philosophy, Gilles Deleuze: Key Concepts offers an easy to access primer to reading Deleuze. (shrink)

Aristotle assesses as valid three first figure syllogisms, each of which contains at least one premiss expressing a de re contingency. In fact, all three of these moods (namely, Barbara-QQQ, Barbara-XQM, and Barbara-LQM) are invalid. Utilizing the concept of ampliation, this paper shows how the mood Barbara-QQQ must be refined if it is to be deemed valid. It can then become clear as to how Barbara-XQM and Barbara-LQM can be disambiguated and ultimately validated. In treating all three moods, some theses (...) from S4 will be exploited in the context of distinguishing de dicto and de re modes of attributing possibility and necessity. Various Aristotelian propositional forms and rules of inference, including argumentation by ecthesis, will shape the presentation. The viability of Aristotle’s views on the convertibility of universal negative apodeictic propositions will emerge as decisive in evaluating the success of his modal syllogistic. (shrink)

The first part of the paper sketches the rationale for the classical theistic thesis that, though God is not really related to the world, the world is really related to God. Part II delineates four sets of recent criticisms ofthis thesis: (a) an objection which assesses it as conflating transparent and opaque construals of intentional propositions, (b) a dilemma which regards it as undermining either free divine creativity or God’s knowledge of the contingent, (c) arguments which view its adherence to (...) an absolute divine immutability and independence as in conflict both with God’s knowledge of a changing creation and with human knowledge of God, and (d) two religiously inspired objections which contend that the thesis is contradictory to the biblical claim that God is personally related to the world. Part III develops the linguistic essence of the classical thesis through the syntactical insights of Sommers’ logic and defends it against the objections posed. (shrink)

The first part of the paper sketches the rationale for the classical theistic thesis that, though God is not really related to the world, the world is really related to God. Part II delineates four sets of recent criticisms ofthis thesis: (a) an objection which assesses it as conflating transparent and opaque construals of intentional propositions, (b) a dilemma which regards it as undermining either free divine creativity or God’s knowledge of the contingent, (c) arguments which view its adherence to (...) an absolute divine immutability and independence as in conflict both with God’s knowledge of a changing creation and with human knowledge of God, and (d) two religiously inspired objections which contend that the thesis is contradictory to the biblical claim that God is personally related to the world. Part III develops the linguistic essence of the classical thesis through the syntactical insights of Sommers’ logic and defends it against the objections posed. (shrink)

I present an argument which is related to the ontological argument which has a more plausible premise and a weaker conclusion. I assume two postulates concerning the meaning of ‘x creates y’. I then prove that the proposition possibly, something (non-vacuously) creates everything entails, in quantified S5, that there is a necessarily existing object with creative power - an object which creates all (and some) contingently existing objects in some possible world.